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Archive for March, 2015

Many Hispanics don’t call 911 for fear of police

Mar
30

Date: March 30th, 2015

Low income residents living in minority neighborhoods have been found to have some two strikes that are against them. First, these persons usually have higher incidences of cardiac arrest happening out of hospital than average and secondly,

Doing more for patients doesn’t always mean better results

Mar
28

Date: March 28th, 2015

The last five decades have seen the pharmaceuticals; surgical procedures and medical devices undergo some remarkable advances. As a result of this, it comes as no surprise that many people are always looking for more invasive care compared to what they used to get previously.

Little known adverse effects of CPR

Mar
26

Date: March 26th, 2015

The issue of end of life care in Canada has been well underway and there has been a lot of legal, political, public and medical debate about it. You will find regular comments about it in not only the medical journals but also in the general press as well.

How Epinephrine affects cardiac arrest survival

Mar
24

Date: March 24th, 2015

Epinephrine is essentially an adrenaline that is administered to cardiac arrest patients before arriving at the hospital. It’s administration should definitely be part of first aid certification training for paramedics. It has come to be linked with reduced chances of survival and has no substantial mental disability as far as the results of an observational study are concerned. For those people who recovered spontaneous circulation instantly, only 17 percent of those who got Epinephrine were able to survive up to a point of being discharged from the hospital with a Category 1 or 2 of cerebral performance. This is in comparison to just 60 percent of those who never received the drug.

Pure alpha- adrenergic drug

According to a propensity subanalysis matched with the score, surviving cardiac arrest with a relatively good neurologic outcome continued to be less common for the group that received Epinephrine. Adjusted odds ratio of the same revealed that there was a risk dependent with the dose for the group that never got Epinephrine.

  • 0.48 for 1 Epinephrine mg with 95 percent confidence interval, i.e. 0.27- 0.84
  • 0.3 for between 2 and 5 mg of Epinephrine with 95 percent CI, i.e. 0.20 – 0.47
  • 0.23 for over 5 mg of Epinephrine with 95 percent CI, i.e. 0.14 – 0.37

The release of these findings comes at a time when there has been increased evidence that has been questioning the actual role that the guideline- recommended vasopressor administered for cardiac arrest out of hospital. According to the lead researcher, the main reason explaining this could be linked to timing or simply due to the fact that the adrenaline isn’t capable of getting the job done in the best way possible.

In a recent animal research, it was seen that when ventricular fibrillation arrest was in the circulatory phase, additional of a better adrenergic blocked could offer some help unlike when pure alpha- adrenergic drug is added like methoxamine or phenylephrine which didn’t. There is need for further research both in humans and animal models to help in assessing if a combination of agents or just pure alpha agent could be much more superior and better than Epinephrine especially during the resuscitation phase.

Epinephrine timing

In the study, the researchers found that delayed administration of Epinephrine was associated with much worse outcomes for the patients who had been admitted in a Paris Hospital with a single but a large cardiac arrest. Out of the 1, 556 patients who were included in the study, only 73 percent of them had actually received Epinephrine. However, it is worth noting that the outcome of this wasn’t really as bad when compared to no Epinephrine particularly when administration of the adrenaline was done soon after the person suffered a cardiac arrest. According to these findings, the researchers noted that proper timing of Epinephrine is crucial to enhancing chances of survival of any person with out of hospital cardiac arrest.

How to help patients of anaphylaxis

Mar
22

Date: March 22nd, 2015

Anaphylaxis is an allergic reaction that can be life threatening and can lead to shock which is essentially a condition where blood pressure drops suddenly and can result in trouble breathing. For allergic persons, anaphylaxis tends to occur just a few minutes after the person is exposed to an allergen- allergy causing substance.